Isocapnic Validation Study

Tomasz Kowalski
Sport Science Researcher
Tomasz Kowalski
Sport Science Researcher

A new study has just been published in the peer-reviewed journal Biology by Tomasz Kowalski of Warsaw, Poland. Keen observers may remember some of his earlier work with speed skaters and triathletes, which confirmed the physiologic benefits of respiratory muscle training. In his most recent publication, he investigates the effects of the BWB (Breathe Way Better) device on blood chemistry at both sea level and simulated altitude.

The results provide strong confirmation that the BWB does exactly what it was designed to do: balance carbon dioxide concentrations in the blood and maintain normal homeostasis of blood pH. This is the first peer-reviewed paper to directly examine the biochemical evidence supporting our long-standing assertion that BWB is both safe and effective.

Findings at Sea Level (Normoxia)

When tested below 1,000m of elevation, only one blood chemistry value shifted significantly after BWB use: pO2 (partial pressure of oxygen, is a measure of how much oxygen is dissolved in the blood). Across all sessions, regardless of duration, blood oxygen rose by 12–13%—from lows of 67–75 mmHg up to 75–85 mmHg.

The author notes this increase could, in theory, contribute to endothelial stress or inflammation. However, studies on carefully controlled hyperoxia (exposure to elevated oxygen levels) also show benefits, including increased tissue oxygenation, improved aerobic metabolism, and enhanced performance. Importantly, even with this increase, blood oxygen values remained well within the normal physiologic range for healthy individuals.

Findings at Altitude (Hypoxia)

Testing was conducted at a simulated altitude of 4,200m (nearly 14,000 feet). Sessions lasted only 5 minutes. Here, small changes in pH and bicarbonate (HCO3–) were noted, but pH consistently stayed in the normal physiologic range (below 7.45).

More striking was the change in oxygen levels. Despite starting with very low baseline values, pO2 rose 13%—from 46.9 mmHg to 51.7 mmHg—even while breathing air containing just 12% oxygen. In other words, athletes increased their oxygenation after only 5 minutes of BWB training. This finding aligns with our field observations: athletes experiencing acute altitude sickness symptoms have often reversed them quickly with BWB use.

6x World Champion Cory Wallace
6x World Champion Cory Wallace

Using the BWB when racing at altitude is a complete game changer for me

Safety Considerations

During hypoxic sessions, partial pressure of carbon dioxide (pCO2) did decrease, though only into the low-normal range. This serves as an important reminder: BWB training, particularly at altitude, should be carefully monitored. We strongly recommend pulse oximetry and heart rate monitoring, always under the guidance of a qualified coach.

Final Thought

We’re excited that this research confirms the physiologic stability that has always been central to our claims. The BWB continues to prove itself as a safe and effective tool for respiratory training—both in everyday use and in challenging environments. We look forward to sharing new programs and protocols to help you maximize the benefits of your device.

Check out the research paper here!

Learn more about using Isocapnic at altitude

or

Learn more about using Isocapnic for (AMS) Acute Mountain Sickness.

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